Koaksil – an antidepressant from the group of tricyclic derivatives . Active ingredient – tianeptine . The mechanism of action ” Coax ” is associated with increased reverse neuronal uptake of serotonin neurons in the cerebral cortex and hippocampus. Increases the spontaneous activity of pyramidal cells and increases their rate of recovery of functional suppression.
The nature of mood disorders at an intermediate position between the stimulating and sedating antidepressants. Of drug addiction , the effect of ” coax ” in uncontrolled doses compared with heroin.

For a long time, ” Coaxil ” appointed as one of the safest antidepressant was offered as a treatment for heroin addiction. One of the few antidepressants sold without a prescription. In the directions for use , and to this day , in ” The pharmacological properties,” says – ” … is not addictive .”

Thanks to the ” brilliant ” advertising campaign of the company ” Servier ” Coaxil known for a wide range of physicians and patients. And, for about the last two or three years, the notorious …

The first patient with the dependence on coaxial met in my practice about three years ago. I have long , carefully , find out the history of the disease, complaint. Prior to coax , the patient has tried a lot of drugs. But preferred to ” opiates ” . State of intoxication and withdrawal coax also , according to her , were both at ” opiates ” . In fairness it should be noted that the dose (30 tablets per day) was ten times higher than the recommended in the manual . When told his colleagues at the clinic, they were initially believed. And when they believed , was seen as casuistry , a misunderstanding. This first case was already forgotten, but six months later there was a second …

There is currently no published serious research to explain why ” Coaxil ” , differing in chemical structure and mechanism of action of opiates cause similar clinical picture of dependence, both physical, and mental manifestations. However, the fact of this ” similarity ” is now rare argue psychiatrist .

Of distinctive features, in my experience, there are few longer period of formation of the “system” (2-4 weeks) , the prevalence in the structure of withdrawal headaches , depression and psychopathic reactions. Additional effects on the body structure non- CNS often occur in comparison with heroin severe thrombosis and thrombophlebitis often lead to gangrene and amputation followed . This occurs when using coax intravenously.

Currently, many addicts use koaksil as a substitute opiate drugs, and it can be quite legal to buy over the counter , and the process of its preparation for intravenous doses does not require time-consuming or introduce some additional ingredients. But the most unpleasant thing in all this is that in addition to physical dependence on the drug causes extreme psychological dependence , and is destructive to the body as a whole , while much stronger than the same heroin or opium.

In 2006, the year in one of the pharmaceutical publications found information that ” Coaxil ” became the leader in sales in absolute monetary terms of all psychotropic drugs in Russia . In parallel with this , the journal anonymous advice rehabilitation program “Outlook” for 2006 , several times increase in the number of appeals on the issue based on Coax , compared with the previous year . Palm among the ” heavy dependence ” Coaxil lost only heroin.

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